The "abomination of desolation" spoken of by the prophet Daniel and referred to by Jesus in Matthew 24:15-22 in the Olivet Discourse takes place in the book Desecration when Nicolae Carpathia desecrates the Jewish Temple by sacrificing a genetically modified pig in the Holy of Holies and splashing its blood upon the altar. He also attempts to have the golden image of himself brought into the Temple so people can worship him as God. This event, which was broadcast on live television, though interspersed with Chaim Rosenzweig's commentary about the event, outrages the Jews to the point where they are calling for Carpathia's blood, and their response causes Nicolae to break the seven-year agreement of protection for Israel. From that point on, the Temple is never used again, and it is later destroyed by God in Kingdom Come.
In actual history, before Jesus' first coming, King Antiochus IV of the Seleucid Empire (who himself was a precursor to the Antichrist) had set up the "abomination of desolation" (an altar to the Greek god Zeus) in the Jewish Temple, causing outrage by the Jews and thus leading to the Maccabean Revolt, as recorded in the deuterocanonical books of 1st and 2nd Maccabees.